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Index > Protein center > CLEC7A(Gene name) > Human
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  • CLEC7A (Gene name),
  • C-type lectin domain family 7 member A (Protein name ),  CLC7A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CLEC7A(UNQ539/PRO1082;BGR;CLECSF12;DECTIN1);
    Protein name:
    C-type lectin domain family 7 member A;
    Alternative:
    C-type lectin superfamily member 12;Beta-glucan receptor;Dendritic cell-associated C-type lectin 1(DC-associated C-type lectin 1;Dectin-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer (By similarity). Isoform 5 interacts with RANBP9.
    Function:
    Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.
    Subcellular Location:
    Isoform 7 Cytoplasm
    Protein Attributes:
    Sequence length:
    247
    Sequence:
    50:
    MEYHPDLENL | DEDGYTQLHF | DSQSNTRIAV | VSEKGSCAAS | PPWRLIAVIL | 
    100:
    GILCLVILVI | AVVLGTMAIW | RSNSGSNTLE | NGYFLSRNKE | NHSQPTQSSL | 
    150:
    EDSVTPTKAV | KTTGVLSSPC | PPNWIIYEKS | CYLFSMSLNS | WDGSKRQCWQ | 
    200:
    LGSNLLKIDS | SNELGFIVKQ | VSSQPDNSFW | IGLSRPQTEV | PWLWEDGSTF | 
    247:
    SSNLFQIRTT | ATQENPSPNC | VWIHVSVIYD | QLCSVPSYSI | CEKKFSM
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    MIM:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human C-type lectin domain family 7 member A
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    E14873b
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    Packing:
    96T
    ELISA Kit for Human C-type lectin domain family 7 member A
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    E14873h
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    ELISA Kit for Human C-type lectin domain family 7 member A
    Cat.:
    E14873m
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    Packing:
    96T
    CLIA Kit for Human C-type lectin domain family 7 member A
    Cat.:
    U14873m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human C-type lectin domain family 7 member A
    Cat.:
    U14873h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human C-type lectin domain family 7 member A
    Cat.:
    U14873b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human C-type lectin domain family 7 member A
    Cat.:
    P14873Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C-type lectin domain family 7 member A
    Cat.:
    P14873Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C-type lectin domain family 7 member A
    Monoclonal Antibody for Human C-type lectin domain family 7 member A
    Monoclonal Antibody for Human C-type lectin domain family 7 member A
    Monoclonal Antibody for Human C-type lectin domain family 7 member A
    Protein for Human C-type lectin domain family 7 member A
    Protein for Human C-type lectin domain family 7 member A
    Protein for Human C-type lectin domain family 7 member A

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex."
      Sobanov Y. , Bernreiter A. , Derdak S. , Mechtcheriakova D. , Schweighofer B. , Duechler M. , Kalthoff F. , Hofer E.
      Eur. J. Immunol.31:3493-3503(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1."
      Yokota K. , Takashima A. , Bergstresser P.R. , Ariizumi K.
      Gene272:51-60(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
      tissue: Peripheral blood leukocyte.
    3. 3.
      "Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells."
      Hermanz-Falcon P. , Arce I. , Roda-Navarro P. , Fernandez-Ruiz E.
      Immunogenetics53:288-295(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 7);TISSUE SPECIFICITY
      tissue: Peripheral blood leukocyte.
    4. 4.
      "Characterization of the human beta-glucan receptor and its alternatively spliced isoforms."
      Willment J.A. , Gordon S. , Brown G.D.
      J. Biol. Chem.276:43818-43823(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 7; 8 AND 10);FUNCTION;TISSUE SPECIFICITY
      tissue: Peripheral blood leukocyte.
    5. 5.
      "Molecular and functional characterization of human Dectin-1."
      Gruenebach F. , Weck M.M. , Reichert J. , Brossart P.
      Exp. Hematol.30:1309-1315(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INDUCTION;TISSUE SPECIFICITY
      tissue: Dendritic cell.
    6. 6.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 5 AND 7)
      tissue: Umbilical cord blood.
    8. 8.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 9)
      tissue: Colon.
      tissue: Lung.
      tissue: Urinary bladder.
    11. 11.
      "Human Dectin-1 isoform E is a cytoplasmic protein and interacts with RanBPM."
      Xie J. , Sun M. , Guo L. , Liu W. , Jiang J. , Chen X. , Zhou L. , Gu J.
      Biochem. Biophys. Res. Commun.347:1067-1073(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RANBP9;SUBCELLULAR LOCATION
    12. 12.
      "Dectin-1 promotes fungicidal activity of human neutrophils."
      Kennedy A.D. , Willment J.A. , Dorward D.W. , Williams D.L. , Brown G.D. , DeLeo F.R.
      Eur. J. Immunol.37:467-478(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANDF4
    14. 14.
      "Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity."
      Cunha C. , Di Ianni M. , Bozza S. , Giovannini G. , Zagarella S. , Zelante T. , D'Angelo C. , Pierini A. , Pitzurra L. , Falzetti F. , Carotti A. , Perruccio K. , Latge J.P. , Rodrigues F. , Velardi A. , Aversa F. , Romani L. , Carvalho A.
      Blood116:5394-5402(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM
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